George Negroponte was born in New York City in 1953. He studied art at Yale University with Bernard Chaet and William Bailey. Since 1980 he has had fourteen one-person shows at: Brooke Alexander Gallery, John Good, Jason McCoy Inc. in New York City, and P37 in Athens, Greece. His work has been included in numerous exhibitions at other galleries and museums around the world including The Museum of Modern Art and The Metropolitan Museum of Art in New York City.

He has been reviewed by every major art periodical including The New York Times, Artforum, Art in America, ARTnews and The New Criterion. He has taught painting and drawing for over two decades at The Studio School, Parsons School of Design, The School of Visual Arts and Princeton University. He has organized several shows including On Line at Feigen Contemporary in 2003, Drawing in The Present Tense at Parsons School of Design in 2000 and Bernard Chaet at the Studio School in 1997. He has also written on many contemporary artists.

He was Co-Chairman of The Board of The Drawing Center from 1997-2002 and was appointed the first President of the institution in 2002. He moved to Stockholm Sweden in 2007 with his wife and three children where he is making work in his studio on a full time basis.